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首页> 外文OA文献 >Modulation of brain response to emotional conflict as a function of current mood in bipolar disorder: preliminary findings from a follow-up state-based fMRI study
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Modulation of brain response to emotional conflict as a function of current mood in bipolar disorder: preliminary findings from a follow-up state-based fMRI study

机译：双相情感障碍对情绪冲突的脑反应调节与当前情绪的关系：一项基于状态的功能磁共振成像研究的初步发现

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We used functional magnetic resonance imaging (fMRI) to examine affective control longitudinally in a group of patients with bipolar disorder (BD). Participants comprised 12 BD patients who underwent repeated fMRI scans in euthymic (n=11), depressed (n=9), or hypomanic (n=9) states, and were compared with 12 age-matched healthy controls. During fMRI, participants performed an emotional face-word interference task with either low or high attentional demands. Relative to healthy controls, patients showed decreased activation of the cognitive control network normally associated with conflict processing, more severely during hypomania than during depression, but regardless of level of task demand in both cases. During euthymia, a decreased response to conflict was observed only during the high load condition. Additionally, unlike healthy participants, patients exhibited deactivation in several key areas in response to emotion-conflict trials - including the rostral anterior cingulate cortex during euthymia, the hippocampus during depression, and the posterior cingulate cortex during hypomania. Our results indicate that the ability of BD patients to recruit control networks when processing affective conflict, and the abnormal suppression of activity in distinct components of the default mode network, may depend on their current clinical state and attentional demand.
机译：我们使用功能磁共振成像（fMRI）来纵向检查一组躁郁症（BD）患者的情感控制。参加者包括12名BD患者，他们在正常状态（n = 11），抑郁状态（n = 9）或躁狂状态（n = 9）下进行了功能磁共振成像扫描，并与12名年龄匹配的健康对照进行了比较。在功能磁共振成像期间，参与者以低或高注意力需求执行了情绪化的面部单词干扰任务。相对于健康对照，患者表现出通常与冲突处理相关的认知控制网络的激活降低，在轻躁狂期间比抑郁期间更为严重，但无论这两种情况下的任务需求水平如何。在胸膜炎期间，仅在高负荷条件下观察到对冲突的反应降低。此外，与健康参与者不同，患者对情绪冲突试验的反应在几个关键区域表现出失活-包括在胸膜炎期间的鼻前扣带回皮层，抑郁症期间的海马以及在躁狂症发作期间的扣带回皮层。我们的结果表明，BD患者在处理情感冲突时能否招募控制网络，以及在默认模式网络的不同组件中异常抑制活动，可能取决于他们当前的临床状态和关注需求。

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